Prof. Dr. Olga Sergeeva

 

Research Interest

Structure and function of ionotropic receptors in the context of behavioral state. We study the cellular and molecular basis of physiological and pathophysiological processes in the brain, in particular the hypothalamic regulation of sleep and waking, energy administration and motivation. Electrophysiological, molecular biological and histochemical methods reveal the functional correlates of altered gene expression, synaptic plasticity and learning as well as aging in selected cell populations of hypothalamus, hippocampus and basal ganglia in (transgenic) rodents.

Specific Projects

  • GABAA-ergic tonus in sleep, anaesthesia and hepatic encephalopathy
  • The histaminergic and orexinergic systems in brain
  • Peripheral and central cytokines acting in the hypothalamus (fatigue, metabolic syndrome)
  • Interactions between histaminergic and dopaminergic systems in the brain: new therapeutic strategy for Parkinson’s disease

 

Selected Publications

01. Sergeeva OA, De Luca R, Mazur K, Chepkova AN, Haas HL, Bauer A. (2017) N-oleoyldopamine modulates activity of midbrain dopaminergic neurons through multiple mechanisms. Neuropharmacology Jun;119:111-122. doi: 10.1016/j.neuropharm.2017.04.011. undefinedPubMed

02. De Luca R, Suvorava T, Yang D, Baumgartel W, Kojda G, Haas HL, Sergeeva OA (2016) Identification of histaminergic neurons through histamine 3 receptor-mediated autoinhibition. Neuropharmacology. 2016 Jul;106:102-15. doi: 10.1016/j.neuropharm.2015.08.025. undefinedPubMed

03. Yanovsky, Y., Li, S., Yao, Q., Klyuch, B.P., Fleischer, W., Blandina, P., Passani, M.B., Lin, J.S., Haas, H.,L., Sergeeva, O.A. (2011) L-Dopa activates histaminergic neurons. J.Physiol. 589:1349-1366. undefinedPubMed

04. Sergeeva, O. A., Kletke, O., Kragler, A., Poppek, A., Fleischer, W., Schubring, S. R., Görg, B., Haas, H. L., Zhu, X. R., Lübbert, H., Gisselmann, G., Hatt, H. (2010). Fragrant dioxane derivatives identify β1 subunit-containing GABAA receptors. J. Biol. Chem. 285:23985-23993. undefinedPubMed

05. Parmentier, R., Klyuch, B. P., Vandael, D., Lin, J. S., Selbach, O., Haas, H. L., Sergeeva, O. A. (2009). Excitation of histaminergic tuberomamillary neurons by thyrotropin-releasing hormone. J. Neurosci. 29:4471-4483. undefinedPubMed

06. Korotkova TM, Klyuch B, Lin JS, Ponomarenko AA, Haas HL and Sergeeva OA (2007) Modafinil inhibits midbrain dopaminergic neurons through D2-receptors  Neuropharmacology. 52(2): 626-33. undefinedPubMed

07. Sergeeva OA, Schulz D, Doreulee N, Ponomarenko AA, Selbach O, Borsch E, Kircheis G, Huston JP, Haussinger D, Haas HL. (2005) Deficits in cortico-striatal synaptic plasticity and behavioral habituation in rats with portacaval anastomosis.  Neuroscience. 134(4):1091-8. undefinedPubMed

08. Sergeeva, O. A., Fleischer, W., Chepkova, A. N., Warskulat, U., Häussinger, D., Siebler, M., Haas, H. L. (2007). GABAA-receptor modification in taurine transporter knockout mice causes striatal disinhibition. J. Physiol. 585:539-548. undefinedPubMed

09. Korotkova, T. M., Sergeeva, O. A., Eriksson, K. S., Haas, H. L., Brown R. E. (2003) . Excitation of ventral tegmental area dopaminergic and non-dopaminergic neurons by orexins/ hypocretins. J. Neurosci. 23:7-11. undefinedPubMed

10. Eriksson, K. S., Sergeeva, O. A., Brown, R. E., Haas, H. L. (2001). Orexin/Hypocretin Excites the Histaminergic Neurons of the Tuberomamillary Nucleus. J. Neurosci. 21:9273-9279. undefinedPubMed

Moleculare Neurophysiology

Prof. Dr. Olga Sergeeva

Molecular Neurophysiology
Heinrich Heine University
Universitätsstraße 1
40225 Düsseldorf

Tel.: +49 211 81-11981
Verantwortlich für den Inhalt: E-Mail sendenNeuroscience Network Düsseldorf