Prof. Dr. Orhan Aktas

Research Interest

Overall interest: Clinical and experimental neuroimmunology Clinical focus:

  • Multiple Sclerosis and related inflammatory diseases of the CNS
  • Neuromyelitis optica (NMO or Devic’s syndrome) and NMO-spectrum disorders
  • Development of novel clinical markers for neurodegeneration such as optical coherence tomography (OCT)
  • Transfer of novel therapy strategies into clinical studies (investigator-initiated trials, IITs)

Experimental focus:

  • Mechanisms of inflammatory degeneration and disturbed regeneration in the CNS
  • Epigenetic regulation of neural progenitor cell (NPC) homeostasis, with focus on redox-dependent histone deacetylases (sirtuins)
  • Experimental autoimmune encephalomyelitis (EAE)


Selected Publications

1. Kleiter, I., Hellwig, K., Berthele, A., Kümpfel, T., Linker, R.A., Hartung, H.-P., Paul, F.*, Aktas, O.*, for the Neuromyelitis Optica Study group (NEMOS) (2012). Failure of Natalizumab to Prevent Relapses in Neuromyelitis Optica. Arch Neurol. 69(2):239-45. * equal contribution undefinedPubMed

2. Seifert, U., Bialy, L. P., Ebstein, F., Bech-Otschir, D., Voigt, A., Schröter, F., Prozorovski, T., Lange, N., Steffen, J., Rieger, M., Kuckelkorn, U., Aktas, O., Kloetzel, P.-M.*, Krüger, E.* (2010). Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress. Cell 142:613-24. *equal contribution undefinedPubMed

3. Aktas, O., Kieseier, B., Hartung, H.-P. (2010). Neuroprotection, regeneration and immunomodulation: broadening the therapeutic repertoire in multiple sclerosis. Trends Neurosci. 33:140-152. undefinedPubMed

4. Schulze-Topphoff, U., Prat, A., Prozorovski, T., Siffrin, V., Paterka, M., Herz, J., Bendix, I., Ifergan, I., Schadock, I., Mori, M. A., Van, H. J., Schroter, F., Smorodchenko, A., Han, M. H., Bader, M., Steinman, L., Aktas, O.*, Zipp, F.* (2009). Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system. Nat. Med. 15:788-793. *equal contribution undefinedPubMed

5. Paul, F., Waiczies, S., Wuerfel, J., Bellmann-Strobl, J., Dörr, J., Waiczies, H., Haertle, M., Wer-necke, K. D., Volk, H. D., Aktas, O.*, Zipp, F.*. (2008). Oral High-Dose Atorvastatin Treatment in Relapsing-Remitting Multiple Sclerosis. PLoS ONE 3:e1928. *equal contribution undefinedPubMed

6. Prozorovski, T., Schulze-Topphoff, U., Glumm, R., Baumgart, J., Schroter, F., Ninnemann, O., Siegert, E., Bendix, I., Brustle, O., Nitsch, R., Zipp, F.*, Aktas, O.*. (2008). Sirt1 contributes critically to the redox-dependent fate of neural progenitors. Nat. Cell Biol. 10:385-394. *equal contribution undefinedPubMed

7. Zipp, F., Aktas, O. (2006). The brain as a target of inflammatory processes: common pathways link inflammatory and neurodegenerative diseases. Trends Neurosci. 29:518-527 undefinedPubMed

8. Aktas, O.*, Smorodchenko, A.*, Brocke, S., Infante-Duarte, C., Topphoff, U. S., Vogt, J., Prozorovski, T., Meier, S., Osmanova, V., Pohl, E., Bechmann, I., Nitsch, R., Zipp, F. (2005). Neuronal damage in autoimmune neuroinflammation mediated by the death ligand TRAIL. Neuron 46:421-432. *equal contribution undefinedPubMed

9. Aktas, O.*, Prozorovski, T.*, Smorodchenko, A., Savaskan, N. E., Lauster, R., Kloetzel, P.-M., Infante-Duarte, C., Brocke, S., Zipp, F. (2004). Green tea epigallocatechin-3-gallate mediates T cellular NF-kappaB inhibition and exerts neuroprotection in autoimmune encephalomyelitis. J. Immunol. 173:5794-5800. *equal contribution undefinedPubMed

10. Aktas, O., Waiczies, S., Smorodchenko, A., Dorr, J., Seeger, B., Prozorovski, T., Sallach, S., Endres, M., Brocke, S., Nitsch, R., Zipp, F. (2003). Treatment of relapsing paralysis in experimental encephalomyelitis by targeting Th1 cells through atorvastatin. J. Exp. Med. 197:725-733. undefinedPubMed

Prof. Dr.
Orhan Aktas

Molecular Neurology Research Group

Prof. Dr. Orhan Aktas

Neurologische Klinik
Heinrich-Heine Universität
Moorenstrasse 5
40225 Düsseldorf
Tel.: +49 211 81-18464
Fax: +49 211 81-18469


Department of Neurology – undefinedMolecular and Translational

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