Jump to contentJump to search
Symbolbild Neurone im Raum
Foto von

Head of the Institute of Neurobiology

Prof. Dr. rer. nat. Christine R. Rose
Institute of Neurobiology
Faculty of Mathematics and Natural Sciences
Universitätsstraße 1
40225 Düsseldorf


Intracellular ion signalling and neuron-glia interaction at central synapses

Maintenance of ion gradients across the plasma membrane is a fundamental property of living cells. In the nervous system, these ion gradients are the basis for electrical excitability and electrical signaling. In addition, ions act as intracellular second messengers, and dynamic changes in the cytosolic ion concentration regulate many cellular processes.

Our institute is devoted to the study and elucidation of intracellular ion signalling in the vertebrate brain, its cellular pathways and its functional consequences under physiological as well as pathophysiological conditions. A special focus is set on the function of astrocytes and their interaction with neurons at glutamatergic synapses of the mouse hippocampus, cortex and cerebellum. Furthermore, we are mainly concentrating on elucidating intracellular sodium signalling as a new form of ionic excitability of neurons and astrocytes.

To this end, we employ dynamic high-resolution imaging such as multi-photon laser scanning microscopy and various electrophysiological techniques in both neurons and glial cells of the mouse brain in situ.

Further information
Selected Publications

see also: PubMed

  1. Rose CR & Verkhratsky A (2023): Sodium homeostasis and signalling: the core and the hub of astrocyte function. Cell Calcium, 2024 Jan:117:102817.doi: 10.1016/j.ceca.2023.102817. Epub 2023 Nov 4. PubMed
  2. Pape N & Rose CR (2023): Activation of TRPV4 channels promotes the loss of cellular ATP in organotypic slices of the mouse neocortex exposed to chemical ischemia. J Physiol Jul;601(14):2975-2990. doi: 10.1113/JP284430. PubMed
  3. Meyer J, Gerkau NJ, Kafitz KW, Patting M, Jolmes F, Henneberger C & Rose CR (2022): Rapid fluorescence lifetime imaging reveals that TRPV4 channels promote dysregulation of neuronal Na+ in ischemia. J Neuroscience 42(4):552-566. doi: 10.1523/JNEUROSCI.0819-21.2021. PubMed
  4. Kalia M, Meijer HGE, van Gils SA, van Putten MJAM & Rose CR (2021): Ion dynamics at the energy-deprived tripartite synapse. PLoS Comput Biol Jun 18;17(6):e1009019. doi: 10.1371/journal.pcbi.1009019. PubMed
  5. Gerkau NJ, Lerchundi R, Nelson JE, Lantermann M, Meyer J, Hirrlinger J & Rose CR (2019): Relation between activity-induced intracellular sodium loading and ATP dynamics in mouse hippocampal neurons. J Physiol 597(23):5687-5705. doi: 10.1113/JP278658. Epub 2019 Oct 30. PubMed
  6. Lerchundi R, Huang N & Rose CR (2020): Quantitative imaging of changes in astrocytic and neuronal ATP using two different variants of ATeam. Front Cell Neurosci 14:80. doi: 10.3389/fncel.2020.00080. PubMed
  7. Ziemens D, Oschmann F, Gerkau NJ & Rose CR (2019): Heterogeneity of activity-induced sodium transients between astrocytes of the mouse hippocampus and neocortex: Mechanisms and consequences. J Neurosci 39 (14): 2620-2634; DOI: doi.org/10.1523/JNEUROSCI.2029-18.2019.
  8. Gerkau NJ, Rakers C, Durry S, Petzold GC, Rose CR (2018): Reverse NCX Attenuates Cellular Sodium Loading in Metabolically Compromised Cortex. Cereb Cortex 28: 4264-4280. doi: 10.1093/cercor/bhx280. PubMed
  9. Steffensen AB, Oernbo EK, Stoica A, Gerkau NJ, Barbuskaite D, Tritsari K, Rose CR, MacAulay N (2018): Cotransporter-mediated water transport underlying cerebrospinal fluid formation. Nat Commun. 2018 Jun 4;9(1):2167. doi: 10.1038/s41467-018-04677-9. PubMed
  10. Petrik D, Myoga MH, Grade S, Gerkau NJ, Pusch M, Rose CR, Grothe B, Götz M (2018): Epithelial sodium channel regulates adult neural stem cell proliferation in a flow dependent manner. Cell Stem Cell. 2018 Jun 1;22(6):865-878.e8. doi: 10.1016/j.stem.2018.04.016. PubMed
Responsible for the content: