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Symbolbild Neurone im Raum
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PD Dr. rer. nat. Carsten Berndt
Department of Neurology
Life Science Center
Merowingerplatz 1a
40225 Düsseldorf

Research Interest

The aim of our research is the elucidation of new functions of oxidoreductases of the thioredoxin family. These enzymes control posttranslational oxidative modifications and FeS cluster biosynthesis and are thereby key players in regulation of redox and iron homeostases. Currently, our projects focus on the identification of redox-dependent cellular processes important for physiological and pathological situations in the central nervous system, such as differentiation of neural stem and progenitor cells, induction, progression, and regeneration of/after neuroinflammation, or invasion of cancer cells.

Further information
Selected Publications
  1. Trnka, D., Engelke, A.D., Gellert, M., Moseler, A., Hossain, M.F., Lindenberg, T.T., Pedroletti, L., Odermatt, B., de Souza, J.V., Boronowska, A.K., Dick, T.P., Mühlenhoff, U., Meyer, A.J., Berndt, C., and Lillig, C.H.
    Molecular basis for the distinct functions of redox-active and FeS-transfering glutaredoxins. Nat Commun 2020 Jul 10;11(1):3445.doi: 10.1038/s41467-020-17323-0. PubMed
  2. Berndt, C., Hanschmann, E.M., Urbainsky, C., Jordt, L.M., Müller, S.C., Bodnar, Y., Schipper, S., Handorf, O., Nowack, R., Moulis, J.M., Schulzke, C., Schünemann, V., and Lillig, C.H.
    FeS-cluster coordination of vertebrate thioredoxins regulates suppression of hypoxia-induced factor 2a through iron regulatory protein 1. bioRxiv, doi.org/11.101/2020.08.04.235721 (2020) bioRxiv
  3. Ingold, I., Berndt, C., Schmitt, S., Doll, S., Poschmann, G., Buday, K., Roveris, A., Peng, X., Portos Freita, F., Seibt, T., Mehr, L., Aichler, M., Walch, A., Lamp, D., Jastroch, M., Miyamoto, S., Wurst, W., Ursini, F., Arnér, E.S.J., Fradejas-Villar, N., Schweizer, U., Zischka, H., Friedmann Angeli, J.P., and Conrad, M.
    Selenium utilization by GPX4is required to prevent hydroperoxide-induced ferroptosis. Cell 2018 Jan 25;172(3):409-422.e21.doi: 10.1016/j.cell.2017.11.048. Epub 2017 Dec 28. PubMed
  4. Sies, H., Berndt, C., and Jones D.P.
    Oxidative Stress. Annu. Rev. Biochem. 2017 Jun 20;86:715-748.doi: 10.1146/annurev-biochem-061516-045037. Epub 2017 Apr 24. PubMed
  5. Lepka, K., Volbracht, K., Bill, E., Schneider, R., Rios, N., Hildebrandt, T., Ingwersen, J., Prozorovski, T., Lillig, C.H., van Horssen, J., Steinman, L., Hartung, H.-P., Radi, R., Holmgren, A., Aktas, O., and Berndt, C.
    Iron-sulfur Glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide released from activated microglia. Glia. 2017 Sep;65(9):1521-1534.doi: 10.1002/glia.23178. Epub 2017 Jun 15. PubMed
  6. Lepka, K., Berndt, C., Hartung, H.P., and Aktas, O.
    Redox events as modulators of neuroinflammatory diseases. Front. Cell Dev. Biol. 2016 Jun 23;4:63.doi: 10.3389/fcell.2016.00063. eCollection 2016. PubMed
  7. Berndt, C., Poschmann, G., Stühler, K., Holmgren, A., and Bräutigam, L.
    Zebrafish heart development is regulated via Glutaredoxin 2 dependent migration and survival of neural crest cells. Redox Biol. 2014 May 2;2:673-8.doi: 10.1016/j.redox.2014.04.012. eCollection 2014. PubMed
  8. Bräutigam, L., Jensen, L.D., Poschmann, G., Nyström, S., Bannenberg, S., Dreij, K., Lepka, K., Prozorovski, T., Montano, S.J., Aktas, O., Uhlén, P., Stühler, K., Cao, Y., Holmgren, A., and Berndt, C.
    Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1. Proc. Natl. Acad. Sci. U S A. 2013 Dec 10;110(50):20057-62.doi: 10.1073/pnas.1313753110. Epub 2013 Nov 25. PubMed
  9. Bräutigam, L., Schütte, L.D., Godoy, J.R., Prozorovski, T., Gellert, M., Hauptmann, G., Holmgren, A., Lillig, C.H., and Berndt, C.
    Vertebrate-specific glutaredoxin is essential for brain development. Proc. Natl. Acad. Sci, USA. 2011 Dec 20;108(51):20532-7.doi: 10.1073/pnas.1110085108. Epub 2011 Dec 2. PubMed
  10. Berndt, C., Hudemann, C., Hanschmann, E.M., Axelsson, R., Holmgren, A., and Lillig, C.H.
    How does iron-sulfur cluster coordination regulate the activity of human glutaredoxin 2? Antioxid. Redox Signal. 2007 Jan;9(1):151-7.doi: 10.1089/ars.2007.9.151. PubMed
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