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Group leader: Molecular Aging Research

Prof. Dr. Jean Krutmann
Leibniz Research Institute for Environmental Medicine
Auf’m Hennekamp 50
40225 Düsseldorf

Research Interest
  • Molecular Aging Research
  • Environmental Medicine
Specific Projects
  • DNA repair deficiency syndromes
  • Photobiology
  • Dermatotoxicology
  • Particle Toxicology
Further information
Selected Publications
  1. Kamenisch, Y., Fousteri, M., Knoch, J., von Thaler, A. K., Fehrenbacher, B., Dolle, M., Kuiper, R., Marc Majora, M., Schaller, M., van Steeg, H., Röcken, M., Krutmann, J.* , Mullenders, L. H.*, Berneburg, M. (2010). Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging. J. Exp. Med. 207:379-390. *These authors contributed equally to this work PubMed
  2. Sydlik, U., Gallitz, I., Albrecht, C., Abel, J., Krutmann, J.*, Unfried, K.* (2009). The compatible solute ectoine protects against nanoparticle-induced neutrophilic lung inflammation. Am. J. Respir. Crit. Care Med. 180:29-35. * These authors contributed equally to this work PubMed
  3. Grether-Beck, S., Salahshour-Fard, M., Timmer, A., Brenden, H., Felsner, I., Walli, R., Füllekrug, J., Krutmann, J. (2008). Ceramide and raft signaling are linked with each other in UVA radiation-induced gene expression. Oncogene 27:4769-4778. PubMed
  4. Fritsche, E., Schäfer, C., Bernsmann, T., Calles, C., Wurm, M., Hübenthal, U., Cline, J. E., Schroe-der, P., Rannug, A., Klotz, L. O., Fürst, P., Hanenberg,  H., Abel, J., Krutmann, J. (2007). Lightening up the UV response by identification of the Arylhydrocarbon Receptor as a cytoplasmatic target for ultraviolet B radiation. Proc. Natl. Acad. Sci. USA 104:8851-8856. PubMed
  5. Schwarz, A., Ständer, S., Berneburg, M., Böhm, M., Kulms, D., van Steeg, H., Große-Heitmeyer, K., Krutmann, J., Schwarz, T. (2002). Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair. Nature Cell Biol 4:26-31. PubMed
  6. Grether-Beck, S., Bonnizi, G., Felsner, I., Timmer, A., Schmitt-Brenden, H., Sies, H., Johnson, J. P., Piette, J., Krutmann, J. (2000). Non-enzymatic triggering of the ceramide signaling cascade by solar ultraviolet A radiation. EMBO J. 19:5793-5800. PubMed
  7. Stege, H., Roza, L., Vink, A. A., Grewe, M., Ruzicka, T., Grether-Beck, S., Krutmann, J. (2000). Enzyme plus light therapy to repair DNA damage in ultraviolet-B-irradiated human skin. Proc. Natl. Acad. Sci. USA 97:1790-1795. PubMed
  8. Morita, A., Werfel, T., Stege, H., Ahrens, C., Karmann, K., Grewe, M., Grether-Beck, S., Ruzicka, T., Kapp, A., Klotz, L. O., Sies, H., Krutmann, J. (1997). Evidence that singlet oxygen-induced human T-helper cell apoptosis is the basic mechanism of ultraviolet-A radiation phototherapy. J. Exp. Med. 186:1763-1768. PubMed
  9. Ahrens, C., Grewe, M., Berneburg, M., Grether-Beck, S., Quilliet, S., Mezzina, M., Sarasin, A., Lehmann, A. R., Arlett, C. F., Krutmann, J. (1997). Photocarcinogenesis and inhibition of ICAM-1 expression in cells of DNA-repair defective individuals. Proc. Natl. Acad. Sci. USA 94:6837- 6841. PubMed
  10. Grether-Beck, S., Olaizola-Horn, S., Schmitt, H., Grewe, M., Jahnke, A., Johnson, J. P., Briviba, K., Sies, H., Krutmann, J. (1996). Activation of transcription factor AP2 mediates ultraviolet A radiation and singlet oxygen induced expression of the human ICAM-1 gene. Proc. Natl. Acad. Sci. USA 93:14586-14591. PubMed
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