Group leader: Molecular Aging Research
Auf’m Hennekamp 50 40225 Düsseldorf Nordrhein-Westfalen
Prof. Dr. Jean Krutmann
Leibniz Research Institute for Environmental MedicineAuf’m Hennekamp 50 40225 Düsseldorf Nordrhein-Westfalen
Research Interest
- Molecular Aging Research
- Environmental Medicine
Specific Projects
- DNA repair deficiency syndromes
- Photobiology
- Dermatotoxicology
- Particle Toxicology
Further information
Selected Publications
- Kamenisch, Y., Fousteri, M., Knoch, J., von Thaler, A. K., Fehrenbacher, B., Dolle, M., Kuiper, R., Marc Majora, M., Schaller, M., van Steeg, H., Röcken, M., Krutmann, J.* , Mullenders, L. H.*, Berneburg, M. (2010). Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging. J. Exp. Med. 207:379-390. *These authors contributed equally to this work PubMed
- Sydlik, U., Gallitz, I., Albrecht, C., Abel, J., Krutmann, J.*, Unfried, K.* (2009). The compatible solute ectoine protects against nanoparticle-induced neutrophilic lung inflammation. Am. J. Respir. Crit. Care Med. 180:29-35. * These authors contributed equally to this work PubMed
- Grether-Beck, S., Salahshour-Fard, M., Timmer, A., Brenden, H., Felsner, I., Walli, R., Füllekrug, J., Krutmann, J. (2008). Ceramide and raft signaling are linked with each other in UVA radiation-induced gene expression. Oncogene 27:4769-4778. PubMed
- Fritsche, E., Schäfer, C., Bernsmann, T., Calles, C., Wurm, M., Hübenthal, U., Cline, J. E., Schroe-der, P., Rannug, A., Klotz, L. O., Fürst, P., Hanenberg, H., Abel, J., Krutmann, J. (2007). Lightening up the UV response by identification of the Arylhydrocarbon Receptor as a cytoplasmatic target for ultraviolet B radiation. Proc. Natl. Acad. Sci. USA 104:8851-8856. PubMed
- Schwarz, A., Ständer, S., Berneburg, M., Böhm, M., Kulms, D., van Steeg, H., Große-Heitmeyer, K., Krutmann, J., Schwarz, T. (2002). Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair. Nature Cell Biol 4:26-31. PubMed
- Grether-Beck, S., Bonnizi, G., Felsner, I., Timmer, A., Schmitt-Brenden, H., Sies, H., Johnson, J. P., Piette, J., Krutmann, J. (2000). Non-enzymatic triggering of the ceramide signaling cascade by solar ultraviolet A radiation. EMBO J. 19:5793-5800. PubMed
- Stege, H., Roza, L., Vink, A. A., Grewe, M., Ruzicka, T., Grether-Beck, S., Krutmann, J. (2000). Enzyme plus light therapy to repair DNA damage in ultraviolet-B-irradiated human skin. Proc. Natl. Acad. Sci. USA 97:1790-1795. PubMed
- Morita, A., Werfel, T., Stege, H., Ahrens, C., Karmann, K., Grewe, M., Grether-Beck, S., Ruzicka, T., Kapp, A., Klotz, L. O., Sies, H., Krutmann, J. (1997). Evidence that singlet oxygen-induced human T-helper cell apoptosis is the basic mechanism of ultraviolet-A radiation phototherapy. J. Exp. Med. 186:1763-1768. PubMed
- Ahrens, C., Grewe, M., Berneburg, M., Grether-Beck, S., Quilliet, S., Mezzina, M., Sarasin, A., Lehmann, A. R., Arlett, C. F., Krutmann, J. (1997). Photocarcinogenesis and inhibition of ICAM-1 expression in cells of DNA-repair defective individuals. Proc. Natl. Acad. Sci. USA 94:6837- 6841. PubMed
- Grether-Beck, S., Olaizola-Horn, S., Schmitt, H., Grewe, M., Jahnke, A., Johnson, J. P., Briviba, K., Sies, H., Krutmann, J. (1996). Activation of transcription factor AP2 mediates ultraviolet A radiation and singlet oxygen induced expression of the human ICAM-1 gene. Proc. Natl. Acad. Sci. USA 93:14586-14591. PubMed