Group leader: Immune Mechanisms of Neurological Disorders
Prof. Dr. Norbert Goebels
Department of NeurologyHeinrich-Heine-University
Moorenstraße 5 40225 Düsseldorf
Research Interest
- Immunological effector mechanisms in neurological diseases, with focus on a) antibody associated neurological diseases (e.g. multiple sclerosis, limbic encephalitis, myasthenia gravis); b) the role of CD8+ T cells;
- Organotypic CNS slice cultures as model for: the interaction between immune system and CNS; myelination; immune mediated demyelination and repair;
- Analysis of the intralesional immune cell repertoire
- Recombinant antibody technology
- Spinal cord pathology in MS: Correlation of MRI, elektrophysiology and clinic
- Role of EBV in autoimmunity
- Exploitation of the human immune system for the generation of therapeutic antibodies
Further information
Selected Publications
- B. Sobottka B, Ziegler U, Kaech A, Becher B, Goebels N (2011): CNS live imaging reveals a new mechanism of myelination: The liquid croissant model. Glia 59: 1841 – 1849. PubMed
- Von Büdingen, H.-C., Gulati, M., Kuenzle, S., Fischer, K., Rupprecht. T. A., Goebels, N. (2010). Clonally expanded plasma cells in the cerebrospinal fluid of patients with central nervous system autoimmune demyelination produce “oligoclonal bands”. J. Neuroimmunology 218:134-139. PubMed
- Sobottka, B., Harrer, M. D., Ziegler, U., Wiendl, H., Becher, B., Hünig, T., Goebels, N. (2009). Collateral bystander damage by myelin-directed CD8+ T cells causes axonal loss. Am. J. Pathol. 175:1160-1166. PubMed
- Harrer, M. D., von Büdingen, H.-C., Stoppini, L., Alliod, C., Pouly, S., Fischer, K., Goebels, N. (2009). Live imaging of remyelination after antibody-mediated demyelination in an ex vivo model for immune mediated CNS damage. Exp. Neurol. 216:433-438. PubMed
- Von Büdingen, H.-C., Harrer, M. D., Künzle, S., Meier, M., Goebels, N. (2008). Clonally expanded plasma cells in the cerebrospinal fluid of MS patients produce CNS specific immunoglobulins. Eur. J. Immunol. 38:2014-23. PubMed
- Kuenzle, S., von Büdingen, H.-C., Meier, M., Harrer, M. D., Urich, E., Becher, B., Goebels, N. (2007). Pathogen specificity and autoimmunity distinct features of antigen driven immune responses in neuroborreliosis. Infection and Immunity 75:3842-3847. PubMed
- Greter, M., Heppner, F., Durell, B., Lemos, M., Odermatt, B., Goebels, N., Laufer, T., Noelle, R. J., Becher, B. (2005). Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis. Nature Med. 11:328-334. PubMed
- Skulina, C., Schmidt, S., Dornmair, K., Babbe, H., Roers, A., Rajewsky, K., Wekerle, H., Hohlfeld, R., Goebels, N. (2004). Multiple sclerosis: Brain-infiltrating CD8+ T cells persist as clonal expansions in the CSF and blood. Proc. Natl. Acad. Sci. USA 101:2428-2433. PubMed
- Hofbauer, M., Wiesener, S., Babbe, H., Roers, A., Wekerle, H., Dornmair, K., Hohlfeld, R., Goebels, N. (2003). Clonal tracking of autoaggressive T cells in polymyositis by combining laser microdissection, single-cell PCR and CDR3-spectratype analysis. Proc. Natl. Acad. Sci. USA 100:4090-4095. PubMed
- Babbe, H., Roers, A., Waisman, A., Lassmann, H., Goebels, N., Hohlfeld, R., Friese, M., Schröder, R., Deckert, M., Schmidt, S., Ravid, R., Rajewsky, K. (2000). Clonal expansions of CD8+ T cells dominate the T cell infiltrate in active MS lesions as shown by micromanipulation and single-cell PCR. J. Exp. Med. 192:393-404. PubMed