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Group leader: Immune Mechanisms of Neurological Disorders

Prof. Dr. Norbert Goebels
Department of Neurology
Moorenstraße 5
40225 Düsseldorf

Research Interest
  • Immunological effector mechanisms in neurological diseases, with focus on a) antibody associated neurological diseases (e.g. multiple sclerosis, limbic encephalitis, myasthenia gravis); b) the role of CD8+ T cells;
  • Organotypic CNS slice cultures as model for: the interaction between immune system and CNS; myelination; immune mediated demyelination and repair;
  • Analysis of the intralesional immune cell repertoire
  • Recombinant antibody technology
  • Spinal cord pathology in MS: Correlation of MRI, elektrophysiology and clinic
  • Role of EBV in autoimmunity
  • Exploitation of the human immune system for the generation of therapeutic antibodies
Selected Publications
  1. B. Sobottka B, Ziegler U, Kaech A, Becher B, Goebels N (2011): CNS live imaging reveals a new mechanism of myelination: The liquid croissant model. Glia 59: 1841 – 1849. PubMed
  2. Von Büdingen, H.-C., Gulati, M., Kuenzle, S., Fischer, K., Rupprecht. T. A., Goebels, N. (2010). Clonally expanded plasma cells in the cerebrospinal fluid of patients with central nervous system autoimmune demyelination produce “oligoclonal bands”. J. Neuroimmunology 218:134-139. PubMed
  3. Sobottka, B., Harrer, M. D., Ziegler, U., Wiendl, H., Becher, B., Hünig, T., Goebels, N. (2009). Collateral bystander damage by myelin-directed CD8+ T cells causes axonal loss. Am. J. Pathol. 175:1160-1166. PubMed
  4. Harrer, M. D., von Büdingen, H.-C., Stoppini, L., Alliod, C., Pouly, S., Fischer, K., Goebels, N. (2009). Live imaging of remyelination after antibody-mediated demyelination in an ex vivo model for immune mediated CNS damage. Exp. Neurol. 216:433-438. PubMed
  5. Von Büdingen, H.-C., Harrer, M. D., Künzle, S., Meier, M., Goebels, N. (2008). Clonally expanded plasma cells in the cerebrospinal fluid of MS patients produce CNS specific immunoglobulins. Eur. J. Immunol. 38:2014-23. PubMed
  6. Kuenzle, S., von Büdingen, H.-C., Meier, M., Harrer, M. D., Urich, E., Becher, B., Goebels, N. (2007). Pathogen specificity and autoimmunity distinct features of antigen driven immune responses in neuroborreliosis. Infection and Immunity 75:3842-3847. PubMed
  7. Greter, M., Heppner, F., Durell, B., Lemos, M., Odermatt, B., Goebels, N., Laufer, T., Noelle, R. J., Becher, B. (2005). Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis. Nature Med. 11:328-334. PubMed
  8. Skulina, C., Schmidt, S., Dornmair, K., Babbe, H., Roers, A., Rajewsky, K., Wekerle, H., Hohlfeld, R., Goebels, N. (2004). Multiple sclerosis: Brain-infiltrating CD8+ T cells persist as clonal expansions in the CSF and blood. Proc. Natl. Acad. Sci. USA 101:2428-2433. PubMed
  9. Hofbauer, M., Wiesener, S., Babbe, H., Roers, A., Wekerle, H., Dornmair, K., Hohlfeld, R., Goebels, N. (2003). Clonal tracking of autoaggressive T cells in polymyositis by combining laser microdissection, single-cell PCR and CDR3-spectratype analysis. Proc. Natl. Acad. Sci. USA 100:4090-4095. PubMed
  10. Babbe, H., Roers, A., Waisman, A., Lassmann, H., Goebels, N., Hohlfeld, R., Friese, M., Schröder, R., Deckert, M., Schmidt, S., Ravid, R., Rajewsky, K. (2000). Clonal expansions of CD8+ T cells dominate the T cell infiltrate in active MS lesions as shown by micromanipulation and single-cell PCR. J. Exp. Med. 192:393-404. PubMed
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