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Group leader: Molecular Neurophysiology

Prof. Dr. Olga Sergeeva
Institute of Clinical Neuroscience and Medical Psychology
Moorenstraße 5
40225 Düsseldorf

Research Interest

Structure and function of ionotropic receptors in the context of behavioral state. We study the cellular and molecular basis of physiological and pathophysiological processes in the brain, in particular the hypothalamic regulation of sleep and waking, energy administration and motivation.

Electrophysiological, molecular biological and histochemical methods reveal the functional correlates of altered gene expression, synaptic plasticity and learning as well as aging in selected cell populations of hypothalamus, hippocampus and basal ganglia in (transgenic) rodents.

Specific Projects
  • GABAA-ergic tonus in sleep, anaesthesia and hepatic encephalopathy
  • The histaminergic and orexinergic systems in brain
  • Peripheral and central cytokines acting in the hypothalamus (fatigue, metabolic syndrome)
  • Interactions between histaminergic and dopaminergic systems in the brain: new therapeutic strategy for Parkinson’s disease
Further information
Selected Publications
  1. Sergeeva OA, De Luca R, Mazur K, Chepkova AN, Haas HL, Bauer A. (2017) N-oleoyldopamine modulates activity of midbrain dopaminergic neurons through multiple mechanisms. Neuropharmacology Jun;119:111-122. doi: 10.1016/j.neuropharm.2017.04.011. undefinedPubMed
  2. De Luca R, Suvorava T, Yang D, Baumgartel W, Kojda G, Haas HL, Sergeeva OA (2016) Identification of histaminergic neurons through histamine 3 receptor-mediated autoinhibition. Neuropharmacology. 2016 Jul;106:102-15. doi: 10.1016/j.neuropharm.2015.08.025. undefinedPubMed
  3. Yanovsky, Y., Li, S., Yao, Q., Klyuch, B.P., Fleischer, W., Blandina, P., Passani, M.B., Lin, J.S., Haas, H.,L., Sergeeva, O.A. (2011) L-Dopa activates histaminergic neurons. J.Physiol. 589:1349-1366. undefinedPubMed
  4. Sergeeva, O. A., Kletke, O., Kragler, A., Poppek, A., Fleischer, W., Schubring, S. R., Görg, B., Haas, H. L., Zhu, X. R., Lübbert, H., Gisselmann, G., Hatt, H. (2010). Fragrant dioxane derivatives identify β1 subunit-containing GABAA receptors. J. Biol. Chem. 285:23985-23993. undefinedPubMed
  5. Parmentier, R., Klyuch, B. P., Vandael, D., Lin, J. S., Selbach, O., Haas, H. L., Sergeeva, O. A. (2009). Excitation of histaminergic tuberomamillary neurons by thyrotropin-releasing hormone. J. Neurosci. 29:4471-4483. undefinedPubMed
  6. Korotkova TM, Klyuch B, Lin JS, Ponomarenko AA, Haas HL and Sergeeva OA (2007) Modafinil inhibits midbrain dopaminergic neurons through D2-receptors  Neuropharmacology. 52(2): 626-33. undefinedPubMed
  7. Sergeeva OA, Schulz D, Doreulee N, Ponomarenko AA, Selbach O, Borsch E, Kircheis G, Huston JP, Haussinger D, Haas HL. (2005) Deficits in cortico-striatal synaptic plasticity and behavioral habituation in rats with portacaval anastomosis.  Neuroscience. 134(4):1091-8. undefinedPubMed
  8. Sergeeva, O. A., Fleischer, W., Chepkova, A. N., Warskulat, U., Häussinger, D., Siebler, M., Haas, H. L. (2007). GABAA-receptor modification in taurine transporter knockout mice causes striatal disinhibition. J. Physiol. 585:539-548. undefinedPubMed
  9. Korotkova, T. M., Sergeeva, O. A., Eriksson, K. S., Haas, H. L., Brown R. E. (2003) . Excitation of ventral tegmental area dopaminergic and non-dopaminergic neurons by orexins/ hypocretins. J. Neurosci. 23:7-11. undefinedPubMed
  10. Eriksson, K. S., Sergeeva, O. A., Brown, R. E., Haas, H. L. (2001). Orexin/Hypocretin Excites the Histaminergic Neurons of the Tuberomamillary Nucleus. J. Neurosci. 21:9273-9279. undefinedPubMed
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