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Group leader: Neuroregeneration

Prof. Dr. Patrick Küry
Department of Neurology
Heinrich-Heine-University
Moorenstraße 5
40225 Düsseldorf

Research Interest

My research focuses on neural regeneration processes in the adult nervous system. In this regard we primarily investigate determination, differentiation and maturation of myelinating glial cells. These cells, oligodendrocytes in the central nervous system (CNS) and Schwann cells in the peripheral nervous system (PNS), produce myelin sheaths which enable saltatory nerve conduction and thereby accelerate and intensify neuronal communication. These cells and their myelin sheaths are very sensitive to deleterious exogenous factors and are therefore involved in a number of degenerating diseases such as multiple sclerosis or peripheral neuropathies. We have identified novel stimulatory and inhibitory molecular regulators involved in progenitor and stem cell differentiation and currently investigate their involvement in pathological and regenerative processes.

Further information
Selected Publications
  1. Jadasz, J., Tepe, L., Beyer, F., Samper-Agrelo, I., Akkermann, R., Spitzhorn, L.S., Silva, M.E., Oreffo, R.O.C., Hartung, H.P., Prigione, A., Rivera, F.J., Adjaye, J., and Küry, P. (2017) Human mesenchymal factors induce rat hippocampal- and human neural stem cell dependent oligodendrogenesis. Glia Sep 22. doi: 10.1002/glia.23233. undefinedPubMed
  2. Kremer, D., Göttle, P., Hartung, H.P., and Küry, P. (2016) Pushing forward: Remyelination as the new frontier in CNS diseases. Trends Neurosci. 39(4):246-63. undefinedPubMed
  3. Göttle, P., Sabo, J.K., Heinen, A., Venables, G., Torres, K.J., Tzekova, N., Parras, C., Kremer, D., Hartung, H.P., Cate, H.S., and Küry, P. (2015) Oligodendroglial maturation is dependent on intracellular protein shuttling. J. Neurosci. 35(3): 906-19. undefinedPubMed
  4. Kremer, D., Schichel, T., Förster, M., Tzekova, N., Bernard, C., van der Valk, P., van Horssen, J., Hartung, H.P., Perron, H., and Küry, P. (2013) Human endogenous retrovirus type W envelope protein inhibits oligodendroglial precursor cell differentiation. Ann. Neurol. 74: 721–732. undefinedPubMed
  5. Jadasz, J., Kremer, D., Göttle, P., Tzekova, N., Domke, J., Rivera, F., Adjaye, J., Hartung, H.P., Aigner, L., and Küry, P. (2013) Mesenchymal stem cell conditioning promotes rat oligodendroglial maturation. PLOS ONE 8(8): e71814. doi: 10.1371/journal.pone.0071814. undefinedPubMed
  6. Jadasz J., Rivera F.J., Taubert A., Kandasamy M., Sandner B., Weidner N., Aktas, O., Hartung H.P., Aigner L., and Küry P. (2012) p57kip2 regulates glial fate decision in adult neural stem cells. Development 19: 3306-3315. undefinedPubMed
  7. Kremer, D., Aktas, O., Hartung, H.P. and Küry, P. (2011). The complex world of oligodendroglial differentiation inhibitors. Ann. Neurol. 69: 602-618. undefinedPubMed
  8. Göttle, P., Kremer, D., Jander, S., Ödemis, V., Engele, J., Hartung, H.P., and Küry, P. (2010) Activation of CXCR7 receptor promotes oligodendroglial cell maturation. Ann. Neurol. 68: 915-924. undefinedPubMed
  9. Kremer, D., Heinen, A., Jadasz, J., Göttle, P., Zimmermann, K., Zickler, Ph., Jander, S., Hartung, H.P., and Küry, P. (2009) p57kip2 is dynamically regulated in experimental autoimmune encephalomyelitis and interferes with oligodendroglial maturation. Proc. Natl. Acad. Sci. U. S. A. 106: 9087-9092. undefinedPubMed
  10. Heinen, A., Kremer, D., Göttle, P., Kruse, F., Hasse, B., Lehmann, H., Hartung, H.P., and Küry, P. (2008) The cyclin dependent kinase inhibitor p57kip2 is an intrinsic negative regulator of Schwann cell differentiation. Proc. Natl. Acad. Sci. U. S. A. 105: 8748-8753. undefinedPubMed
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