Prof. Meuth has an interest in researching unconventional or novel therapeutic targets for the treatment of Multiple Sclerosis and other neuroimmunological disorders. His work highlights the importance of innovative and out-of-the-box thinking in developing new strategies for disease management. He is interested in how the immune system interacts with the nervous system, particularly in how immune cells move into the Central Nervous System (CNS). This involves the investigation of specific proteins, such as the endothelial TWIK-related potassium channel-1 (TREK1), which play a role in this process. His cross-disciplinary approaches integrate insights from neurology, immunology, pharmacology, and molecular biology to provide a more comprehensive understanding of neuroimmune interactions and their implications for disease. His translational research focus on the potential therapeutic implications of his findings, such as the identification of non-canonical targets for drug development in Multiple Sclerosis, 'translates' findings from basic science into practical applications to improve human health.

Overall, Prof. Meuth´s work is dedicated to improving our understanding of Multiple Sclerosis and other neuroinflammatory conditions, with a focus on understanding the complex interplay between the immune system and the nervous system, and how this knowledge can be harnessed to develop new therapeutic strategies.

1. Kapell, H., Fazio, L., Dyckow, J., Schwarz, S., Cruz-Herranz, A., Mayer, C., Campos, J., E, D. E., Mobius, W., Cordano, C., Probstel, A. K., Gharagozloo, M., Zulji, A., Narayanan Naik, V., Delank, A. K., Cerina, M., Muntefering, T., Lerma-Martin, C., Sonner, J. K., Sin, J. H., Disse, P., Rychlik, N., Sabeur, K., Chavali, M., Srivastava, R., Heidenreich, M., Fitzgerald, K. C., Seebohm, G., Stadelmann, C., Hemmer, B., Platten, M., Jentsch, T. J., Engelhardt, M., Budde, T., Nave, K. A., Calabresi, P. A., Friese, M. A., Green, A. J., Acuna, C., Rowitch, D. H., Meuth, S. G. & Schirmer, L. Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination. J Clin Invest, doi:10.1172/JCI164223 (2023). PubMed
2. Ruck, T., Bock, S., Pfeuffer, S., Schroeter, C. B., Cengiz, D., Marciniak, P., Lindner, M., Herrmann, A., Liebmann, M., Kovac, S., Gola, L., Rolfes, L., Pawlitzki, M., Opel, N., Hahn, T., Dannlowski, U., Pap, T., Luessi, F., Schreiber, J. A., Wunsch, B., Kuhlmann, T., Seebohm, G., Tackenberg, B., Seja, P., Doring, F., Wischmeyer, E., Chasan, A. I., Roth, J., Klotz, L., Meyer Zu Horste, G., Wiendl, H., Marschall, T., Floess, S., Huehn, J., Budde, T., Bopp, T., Bittner, S. & Meuth, S. G. K_2P18.1 translates T cell receptor signals into thymic regulatory T cell development. Cell Res, doi:10.1038/s41422-021-00580-z (2022).*equal contribution PubMed
3. Bierhansl, L., Hartung, H. P., Aktas, O., Ruck, T., Roden, M. & Meuth, S. G. Thinking outside the box: non-canonical targets in multiple sclerosis. Nat Rev Drug Discov, doi:10.1038/s41573-022-00477-5 (2022). PubMed
4. Schafflick, D., Wolbert, J., Heming, M., Thomas, C., Hartlehnert, M., Borsch, A. L., Ricci, A., Martin-Salamanca, S., Li, X., Lu, I. N., Pawlak, M., Minnerup, J., Strecker, J. K., Seidenbecher, T., Meuth, S. G., Hidalgo, A., Liesz, A., Wiendl, H. & Meyer Zu Horste, G. Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges. Nat Neurosci, doi:10.1038/s41593-021-00880-y (2021). PubMed
5. Gross, C. C., Meyer, C., Bhatia, U., Yshii, L., Kleffner, I., Bauer, J., Troscher, A. R., Schulte-Mecklenbeck, A., Herich, S., Schneider-Hohendorf, T., Plate, H., Kuhlmann, T., Schwaninger, M., Bruck, W., Pawlitzki, M., Laplaud, D. A., Loussouarn, D., Parratt, J., Barnett, M., Buckland, M. E., Hardy, T. A., Reddel, S. W., Ringelstein, M., Dorr, J., Wildemann, B., Kraemer, M., Lassmann, H., Hoftberger, R., Beltran, E., Dornmair, K., Schwab, N., Klotz, L., Meuth, S. G., Martin-Blondel, G., Wiendl, H. & Liblau, R. CD8⁺ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome. Nat Commun, doi:10.1038/s41467-019-13593-5 (2019). PubMed
6. Gobel, K., Asaridou, C. M., Merker, M., Eichler, S., Herrmann, A. M., Geuss, E., Ruck, T., Schungel, L., Groeneweg, L., Narayanan, V., Schneider-Hohendorf, T., Gross, C. C., Wiendl, H., Kehrel, B. E., Kleinschnitz, C. & Meuth, S. G. Plasma kallikrein modulates immune cell trafficking during neuroinflammation via PAR2 and bradykinin release. Proc Natl Acad Sci U S A, doi:10.1073/pnas.1810020116 (2019). PubMed
7. Gobel, K., Kraft, P., Pankratz, S., Gross, C. C., Korsukewitz, C., Kwiecien, R., Mesters, R., Kehrel, B. E., Wiendl, H., Kleinschnitz, C. & Meuth, S. G. Prothrombin and factor X are elevated in multiple sclerosis patients. Ann Neurol, doi:10.1002/ana.24807 (2016). PubMed
8. Mykicki, N., Herrmann, A. M., Schwab, N., Deenen, R., Sparwasser, T., Limmer, A., Wachsmuth, L., Klotz, L., Kohrer, K., Faber, C., Wiendl, H., Luger, T. A., Meuth, S. G. & Loser, K. Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease. Sci Transl Med, doi:10.1126/scitranslmed.aaf8732 (2016). *equal contribution PubMed
9. Gobel, K., Pankratz, S., Asaridou, C. M., Herrmann, A. M., Bittner, S., Merker, M., Ruck, T., Glumm, S., Langhauser, F., Kraft, P., Krug, T. F., Breuer, J., Herold, M., Gross, C. C., Beckmann, D., Korb-Pap, A., Schuhmann, M. K., Kuerten, S., Mitroulis, I., Ruppert, C., Nolte, M. W., Panousis, C., Klotz, L., Kehrel, B., Korn, T., Langer, H. F., Pap, T., Nieswandt, B., Wiendl, H., Chavakis, T., Kleinschnitz, C. & Meuth, S. G. Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells. Nat Commun, doi:10.1038/ncomms11626 (2016). PubMed
10. Bittner, S., Ruck, T., Schuhmann, M. K., Herrmann, A. M., Moha ou Maati, H., Bobak, N., Gobel, K., Langhauser, F., Stegner, D., Ehling, P., Borsotto, M., Pape, H. C., Nieswandt, B., Kleinschnitz, C., Heurteaux, C., Galla, H. J., Budde, T., Wiendl, H. & Meuth, S. G. Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS. Nat Med, doi:10.1038/nm.3303 (2013). PubMed